Kan Ia D, Zverev M P, Dvorkina S Iu
Vopr Onkol. 1988;34(6):713-7.
The report discusses early-onset radiation injuries in the urinary bladder of more than 1000 patients with cancer of the cervix and corpus uteri. Clinical symptoms of such injuries were observed in 487 patients (44.3%). In 47 (10%), the lesions were pronounced. The degree of radiation-induced cystitis was evaluated on a 6-point scale used by WHO classification (1982). Said lesions mainly occurred at stage III of tumor and predominantly in cases of cancer of the corpus uteri. Complications development was stimulated by vascular lesions, diabetes mellitus and inflammatory processes in pelvic organs. Radiation injuries were treated by standard procedures as well as with immobilised trypsin administered in a cellulose powder vehicle. This method proved the most effective. Since patients suffering early-onset radiation-induced destructive injuries are at high risk of further exacerbation at later stages, they should be followed-up closely.
该报告讨论了1000多名子宫颈癌和子宫体癌患者膀胱的早期放射性损伤。487名患者（44.3%）出现了此类损伤的临床症状。47名患者（10%）的损伤较为明显。根据世界卫生组织分类（1982年）使用的6分制对放射性膀胱炎的程度进行评估。所述损伤主要发生在肿瘤III期，且主要发生在子宫体癌病例中。血管病变、糖尿病和盆腔器官的炎症过程会促使并发症的发生。放射性损伤采用标准程序以及以纤维素粉末为载体的固定化胰蛋白酶进行治疗。该方法被证明是最有效的。由于遭受早期放射性诱导的破坏性损伤的患者在后期有进一步恶化的高风险，因此应对他们进行密切随访。
