Department of Neurology, Stroke Center.
Department of Cardiology.
Neurologist. 2021 May 5;26(3):86-89. doi: 10.1097/NRL.0000000000000311.
The concurrency of both, acute stroke and acute myocardial infarction in normal conditions, outside the pandemic is rare. Coagulopathy has been associated with the inflammatory phase of coronavirus disease (COVID-19) and might be involved in this concurrency.
We describe 2 patients with previous mild or no symptoms of COVID-19, admitted for acute stroke with recent/simultaneous myocardial infarction in whom admission polymerase chain reaction was negative but serologic testing diagnosed COVID-19. In these patients, concurrent stroke and myocardial infarction could have been promoted by COVID-19 infection. Management and evolution are detailed, and their contacts to confirm the COVID-19 infection. Pathogenic analysis of possible hypercoagulation state is described suggesting the hypothesis of endothelial dysfunction as the strongest mechanism involved in thrombus formation after the acute phase of COVID-19 infection.
Our experience with these cases suggests that patients with mild symptoms can also present thromboembolic complications once the acute phase of COVID-19 infection has passed.
在大流行期间以外，正常情况下同时发生急性中风和急性心肌梗死的情况较为罕见。凝血病与冠状病毒疾病（COVID-19）的炎症阶段有关，并且可能与这种同时发生有关。
我们描述了 2 例先前 COVID-19 症状轻微或无的患者，因急性中风入院，近期/同时发生心肌梗死，入院聚合酶链反应为阴性，但血清学检测诊断为 COVID-19。在这些患者中，中风和心肌梗死的并发可能是由 COVID-19 感染引起的。详细介绍了治疗和预后，并与他们的接触者确认了 COVID-19 感染。对可能的高凝状态进行了病原分析，提出了内皮功能障碍作为 COVID-19 感染后急性阶段血栓形成最强机制的假设。
我们对这些病例的经验表明，即使 COVID-19 感染的急性期已经过去，症状轻微的患者也可能会出现血栓栓塞并发症。
