Department of Stomatology, The Zhongshan College Affiliated to Dalian Medical University, Dalian, China 116085.
Department of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, China 116044.
Biosci Rep. 2021 May 28;41(5). doi: 10.1042/BSR20210040.
Fam20C is a Golgi kinase phosphorylating the majority of the secreted proteins. In this decade, the function of Fam20C has been largely disclosed in the loss-of function models. How the influence of the overexpressed Fam20C on cells or organs, and whether Fam20C was associated with tumorogensis still remain unknown. In the latest article in Bioscience Reports, a group from The Second Affiliated Hospital of Harbin Medical University established a correlation between the elevated Fam20C expression and the poor prognosis of multiple cancers (Biosci. Rep. (2021), 41(1) BSR20201920). In addition, they also proposed the potential mechanisms how the increased Fam20C expression played a detrimental role in tumor progression by suggesting that the up-regulated Fam20C level affected the infiltration of immune cells and the capability of cancer metastasis. To give an overview of the expanding knowledge of Fam20C involved in the physiological and pathological events, we first reviewed the history of Fam20C study in this commentary, then, evaluated the correlation of the elevated Fam20C expression to the prognosis of multiple cancers, and finally, interpreted the perspectives that the Fam20C gain-of-function model was also critical for cancer therapy.
Fam20C 是一种高尔基体激酶，可磷酸化大多数分泌蛋白。在这十年中，Fam20C 的功能在功能丧失模型中得到了广泛揭示。高表达 Fam20C 对细胞或器官的影响，以及 Fam20C 是否与肿瘤发生有关，仍然未知。在《生物科学报告》（Bioscience Reports）的最新文章中，哈尔滨医科大学第二附属医院的一个研究小组建立了 Fam20C 表达升高与多种癌症预后不良之间的相关性（Biosci. Rep. (2021), 41(1) BSR20201920）。此外，他们还提出了 Fam20C 表达上调在肿瘤进展中发挥有害作用的潜在机制，表明上调的 Fam20C 水平影响免疫细胞的浸润和癌症转移的能力。为了概述 Fam20C 参与生理和病理事件的扩展知识，我们首先在本评论中回顾了 Fam20C 研究的历史，然后评估了 Fam20C 表达升高与多种癌症预后的相关性，最后解释了 Fam20C 功能获得模型对癌症治疗也很重要的观点。
