Zhang Rui, Ren Yanming, Ju Yan, Zhang Yuekang, Zhang Yan, Wang Yuan
Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Genes Dis. 2023 Nov 23;12(2):101179. doi: 10.1016/j.gendis.2023.101179. eCollection 2025 Mar.
Family with sequence similarity 20 C (FAM20C) is a Golgi protein kinase that phosphorylates the serine residue in the S-x-E/pS motif of target proteins. FAM20C phosphorylates most secreted proteins, which play important roles in multiple biological processes, including cancer progression, biomineralization, and lipid homeostasis. Numerous studies have documented the potential contribution of FAM20C to the growth, invasion, and metastasis of glioma, breast cancer, and other cancers, as well as to the mineralization process of teeth and bone. In addition, FAM20C has been found to be associated with the occurrence and development of certain cardiovascular diseases and endocrine metabolism disorders. It raises hopes that understanding the disease-specific mechanisms of FAM20C may hold the key to developing new strategies for these diseases. This review comprehensively covers the existing literature to provide a summary of the structure and biological functions of FAM20C, with a particular focus on its roles in the disease context.
序列相似性家族20成员C（FAM20C）是一种高尔基体蛋白激酶，可磷酸化靶蛋白S-x-E/pS基序中的丝氨酸残基。FAM20C可磷酸化大多数分泌蛋白，这些蛋白在多种生物学过程中发挥重要作用，包括癌症进展、生物矿化和脂质稳态。大量研究记录了FAM20C对胶质瘤、乳腺癌和其他癌症的生长、侵袭和转移以及牙齿和骨骼矿化过程的潜在作用。此外，已发现FAM20C与某些心血管疾病和内分泌代谢紊乱的发生发展有关。这让人希望，了解FAM20C的疾病特异性机制可能是开发这些疾病新策略的关键。本综述全面涵盖现有文献，以总结FAM20C的结构和生物学功能，特别关注其在疾病背景下的作用。
