Key Laboratory of Chemical Biology, Department of Pharmaceutics, School of Pharmaceutical Sciences, Ministry of Education, Shandong University, Jinan, China.
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA.
J Drug Target. 2022 Jan;30(1):46-60. doi: 10.1080/1061186X.2021.1920026. Epub 2021 May 4.
Since the discovery of cell-penetrating peptides (CPP) in the 1980s, they have played a unique role in various fields owing to their excellent and unique cell membrane penetration function. In particular, in the treatment of tumours, CPPS have been used to deliver several types of 'cargos' to cancer cells. To address the insufficient targeting ability, non-selectivity, and blood instability, activatable cell-penetrating peptides, which can achieve targeted drug delivery in tumour treatment, enhance curative effects, and reduce toxicity have been developed. This study reviews the application of different cell-penetrating peptides in tumour-targeted delivery, overcoming multidrug resistance, organelle targeting, tumour imaging, and diagnosis, and summarises the different mechanisms of activatable cell-penetrating peptides in detail.
自 20 世纪 80 年代发现细胞穿透肽（CPP）以来，由于其优异而独特的细胞膜穿透功能，它们在各个领域发挥了独特的作用。特别是在肿瘤治疗中，CPP 已被用于将多种“货物”递送到癌细胞中。为了解决靶向能力不足、非选择性和血液不稳定性的问题，开发了能够在肿瘤治疗中实现靶向药物传递、提高疗效和降低毒性的可激活细胞穿透肽。本研究综述了不同细胞穿透肽在肿瘤靶向递药、克服多药耐药、细胞器靶向、肿瘤成像和诊断中的应用，并详细总结了可激活细胞穿透肽的不同作用机制。
