Department of Epidemiology and Public Health, University of Nottingham.
Department of Rheumatology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Rheumatology (Oxford). 2021 Nov 3;60(11):4982-4990. doi: 10.1093/rheumatology/keab406.
Takayasu arteritis (TAK) is a rare autoimmune rheumatic disease causing large-vessel vasculitis. Onset is typically between the ages of 20 and 30 years. It is associated with substantial morbidity and mortality, notably due to its effects on the cardiovascular system. It has a poorly understood global epidemiology. Our objective was to systematically review the available evidence in order to calculate the incidence rate of TAK.
Three databases (MEDLINE, PubMed and Embase) were searched in November 2019 and the results were screened by two reviewers. A random effects meta-analysis was then conducted in R to calculate the overall incidence rate. Heterogeneity was assessed using I2. The quality of the studies was assessed using an adapted Newcastle-Ottawa scale. Further subgroup analyses were performed by quality, sex, research setting and geographical location. Publication bias was assessed using a Begg's funnel plot.
The incidence rate for TAK was 1.11 per million person-years (95% CI 0.70-1.76). The heterogeneity in the data was extremely high in all analyses, which suggests that there was considerable variation in incidence rates across the different populations studied. TAK was found to be more common in women (incidence rate 2.01 per million person-years, 95% CI 1.39-2.90).
TAK is an extremely rare disease. It affects women more commonly than men. There is considerable variation in the incidence rate between populations. We suggest that future research should focus on discrete populations in order to better identify genetic and environmental risk factors.
Takayasu 动脉炎（TAK）是一种罕见的自身免疫性风湿性疾病，可引起大血管血管炎。发病通常在 20 至 30 岁之间。它与大量的发病率和死亡率有关，特别是由于其对心血管系统的影响。它的全球流行病学尚未得到充分理解。我们的目的是系统地审查现有证据，以计算 TAK 的发病率。
2019 年 11 月，我们在三个数据库（MEDLINE、PubMed 和 Embase）中进行了搜索，并由两名审查员筛选结果。然后，我们在 R 中进行了随机效应荟萃分析，以计算总体发病率。使用 I2 评估异质性。使用改编的 Newcastle-Ottawa 量表评估研究的质量。进一步按质量、性别、研究地点和地理位置进行亚组分析。使用 Begg 漏斗图评估发表偏倚。
TAK 的发病率为 1.11 每百万人年（95%CI 0.70-1.76）。在所有分析中，数据的异质性都非常高，这表明不同研究人群的发病率存在很大差异。TAK 在女性中更为常见（发病率为 2.01 每百万人年，95%CI 1.39-2.90）。
TAK 是一种非常罕见的疾病。它比男性更常见于女性。不同人群的发病率存在很大差异。我们建议未来的研究应集中在特定人群，以更好地确定遗传和环境风险因素。
