Yamamoto M, Nakajo S, Ito M, Tahara E
Department of Pathology, Hiroshima University Hospital, Japan.
Acta Pathol Jpn. 1988 Mar;38(3):393-8. doi: 10.1111/j.1440-1827.1988.tb02311.x.
A case of primary mucosal hyperplasia of the gallbladder in a 55-year-old man is reported. Endoscopic ultrasonography demonstrated diffuse mucosal thickening of the gallbladder which was associated with anomalous union of the pancreatico-biliary duct system. Histologically, the mucosa showed villous and spongioid hyperplasia. The mucosa, which consisted of tall columnar cells that were morphologically similar to ordinary gallbladder epithelium, showed no metaplastic changes such as occurrence of mucous glands, Paneth cells, goblet cells, endocrine cells, or lysozyme immunoreactivity. These findings suggested that this disease was based on hyperplasia of ordinary gallbladder epithelium.
报告了一例55岁男性原发性胆囊黏膜增生病例。内镜超声显示胆囊黏膜弥漫性增厚，这与胰胆管系统的异常汇合有关。组织学上，黏膜表现为绒毛状和海绵状增生。由形态上与普通胆囊上皮相似的高柱状细胞组成的黏膜，未显示化生改变，如黏液腺、潘氏细胞、杯状细胞、内分泌细胞的出现或溶菌酶免疫反应性。这些发现提示该疾病基于普通胆囊上皮的增生。
