Photostable 1-Trifluoromethyl Cinnamyl Alcohol Derivatives Designed as Potential Fungicides and Bactericides.

In the current work, a series of 1-trifluoromethyl cinnamyl alcohol derivatives were designed and synthesized and their antifungal activities were evaluated. The bioassay result showed that most compounds exhibited excellent antifungal activity at 10 μg mL. Next, photostable and easily synthesized compound with broad-spectrum antifungal activity was selected as a potential candidate to evaluate its antibacterial and antifungal activities. The EC values of compound against eight fungal plant pathogens ranged from 3.806 to 17.981 μg mL; at the same time, compound could effectively control , Steinm, West, and in pot experiments. In addition, compound exhibited excellent antibacterial activities and against pv. . Furthermore, the absorption and translocation of compound in wheat plants were determined by the high-performance liquid chromatography method. The result showed that compound could be translocated acropetally as well as basipetally in wheat plants. Finally, it was found that compound had no cross-resistance with carbendazim, azoxystrobin, and boscalid.