Nan Xiaohui, Wang Kaifeng, Sun Xinru, Hu Zhan, Sun Ranfeng
Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Danzhou 571737, China.
Int J Mol Sci. 2025 Jun 2;26(11):5345. doi: 10.3390/ijms26115345.
In response to the urgent need for innovative fungicides to ensure food security and safety, a series of twenty-three novel trifluoromethylpyridine compounds were designed and synthesized using a scaffold hopping strategy derived from dehydrozingerone. This approach involved converting the α, β-unsaturated ketone moiety into a pyridine ring. Bioassay results indicated that the majority of these compounds exhibited promising in vitro antifungal activity, particularly against and . Notably, compound showed the highest efficacy and broad-spectrum activity, with median effective concentrations (EC) ranging from 2.88 to 9.09 μg/mL. Phenoxytrifluoromethylpyridine derivatives, including compound , exhibited superior antifungal activity compared to benzyloxytrifluoromethylpyridine derivatives. In vivo tests revealed that both compounds and exhibited moderate control effects against . The degradation half-lives of compounds and in bananas were determined to be 176.9 h and 94.8 h, respectively, indicating the stability of their structures in the environment. Molecular docking studies indicated that compound interacts with succinate dehydrogenase, offering valuable insights for the structural optimization of compound .
为满足对创新型杀菌剂的迫切需求以确保粮食安全，利用源自脱氢姜酮的骨架跃迁策略设计并合成了一系列23种新型三氟甲基吡啶化合物。该方法涉及将α,β-不饱和酮部分转化为吡啶环。生物测定结果表明，这些化合物中的大多数表现出有前景的体外抗真菌活性，尤其是对……和……。值得注意的是，化合物……显示出最高的功效和广谱活性，其半数有效浓度（EC）范围为2.88至9.09μg/mL。包括化合物……在内的苯氧基三氟甲基吡啶衍生物与苄氧基三氟甲基吡啶衍生物相比表现出优异的抗真菌活性。体内试验表明，化合物……和……对……均表现出中等防治效果。化合物……和……在香蕉中的降解半衰期分别测定为176.9小时和94.8小时，表明它们在环境中结构的稳定性。分子对接研究表明，化合物……与琥珀酸脱氢酶相互作用，为化合物……的结构优化提供了有价值的见解。
