生存在共生体沃尔巴克氏体的世界中：百年综述。
Living in the endosymbiotic world of Wolbachia: A centennial review.
机构信息
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA; Vanderbilt Microbiome Initiative, Vanderbilt University, Nashville, TN 37235, USA.
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA; Vanderbilt Microbiome Initiative, Vanderbilt University, Nashville, TN 37235, USA.
出版信息
Cell Host Microbe. 2021 Jun 9;29(6):879-893. doi: 10.1016/j.chom.2021.03.006. Epub 2021 May 3.
The most widespread intracellular bacteria in the animal kingdom are maternally inherited endosymbionts of the genus Wolbachia. Their prevalence in arthropods and nematodes worldwide and stunning arsenal of parasitic and mutualistic adaptations make these bacteria a biological archetype for basic studies of symbiosis and applied outcomes for curbing human and agricultural diseases. Here, we conduct a summative, centennial analysis of living in the Wolbachia world. We synthesize literature on Wolbachia's host range, phylogenetic diversity, genomics, cell biology, and applications to filarial, arboviral, and agricultural diseases. We also review the mobilome of Wolbachia including phage WO and its essentiality to hallmark reproductive phenotypes in arthropods. Finally, the Wolbachia system is an exemplar for discovery-based science education using biodiversity, biotechnology, and bioinformatics lessons. As we approach a century of Wolbachia research, the interdisciplinary science of this symbiosis stands as a model for consolidating and teaching the integrative rules of endosymbiotic life.
在动物王国中，最广泛存在的细胞内细菌是母系遗传的共生菌属沃尔巴克氏体。它们在全球节肢动物和线虫中的普遍存在，以及令人惊叹的寄生和共生适应能力，使这些细菌成为共生基本研究的生物学原型，以及抑制人类和农业疾病的应用成果。在这里，我们对生活在沃尔巴克氏体世界进行了总结性的百年分析。我们综合了关于沃尔巴克氏体宿主范围、系统发育多样性、基因组学、细胞生物学以及在丝虫、虫媒病毒和农业疾病中应用的文献。我们还回顾了沃尔巴克氏体的可移动基因组，包括噬菌体 WO 及其对节肢动物标志性生殖表型的必要性。最后，沃尔巴克氏体系统是一个基于发现的科学教育的典范，使用生物多样性、生物技术和生物信息学课程。随着我们接近沃尔巴克氏体研究的一个世纪，这种共生关系的跨学科科学为巩固和教授内共生生命的综合规则提供了一个模型。
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