Garcia-Caballero M, Neugebauer E, Campos R, Nunez de Castro I, Vara-Thorbeck C
I Catedra Cirugia, Universidad de Malaga, Spain.
Agents Actions. 1988 Apr;23(3-4):357-60. doi: 10.1007/BF02142587.
Following numerous reports of high histidine decarboxylase (HDC) activity in tumour-bearing animals, the present work was designed to determine the activity of this enzyme in normal and tumour tissues in a series of ten surgical patients with colorectal carcinoma. Significantly increased HDC activity, almost double that of normal tissues, was found in specimens from extirpated human tumours. These results, obtained under reliable sampling and measurement conditions indicated that changes in the enzymic activity of HDC may have a significant role in the development of colorectal tumour cells. Inhibition of the enzyme activity in human cancer subjects may retard or impede tumour growth and perhaps limit the spread of metastases.
在有大量关于荷瘤动物体内组氨酸脱羧酶（HDC）活性高的报道之后，本研究旨在测定10例结直肠癌手术患者的正常组织和肿瘤组织中该酶的活性。在切除的人类肿瘤标本中发现，HDC活性显著增加，几乎是正常组织的两倍。在可靠的采样和测量条件下获得的这些结果表明，HDC酶活性的变化可能在结直肠肿瘤细胞的发展中起重要作用。抑制人类癌症患者体内的酶活性可能会延缓或阻碍肿瘤生长，或许还能限制转移扩散。
