Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
Biomed Pharmacother. 2021 Jul;139:111650. doi: 10.1016/j.biopha.2021.111650. Epub 2021 May 1.
Protein kinases belong to the largest family of enzymes controlling every aspect of cellular activity including gene expression, cell division, differentiation and metabolism. They are part of major intracellular signalling pathways. Hence, it is not surprising that they are involved in the development of major diseases such as cardiovascular disorders, diabetes, dementia and, most importantly, cancer when they undergo mutations, modifications and unbalanced expression. This review will explore the possibility to draw a connection between the application of natural phytochemicals and the treatment of cancer. We have chosen to focus on the PI3K/AKT cellular signalling pathway which has been shown to be a major target by natural compounds in cell cultures and animal models.
蛋白激酶属于控制细胞活动各个方面的最大酶家族，包括基因表达、细胞分裂、分化和代谢。它们是主要细胞内信号通路的一部分。因此，当它们发生突变、修饰和表达失衡时，它们参与心血管疾病、糖尿病、痴呆症等重大疾病的发展就不足为奇了，最重要的是癌症。这篇综述将探讨将天然植物化学物质的应用与癌症治疗联系起来的可能性。我们选择专注于 PI3K/AKT 细胞信号通路，该通路已被证明是细胞培养物和动物模型中天然化合物的主要靶点。
