Zeevi B, Gal D, Wolf N, Berant M, Abramovici A, Blieden L C, Katzir A
Pediatric Cardiology Unit, Beilinson Medical Center, Petah Tiqvah, Israel.
Am Heart J. 1988 Jul;116(1 Pt 1):117-22. doi: 10.1016/0002-8703(88)90258-x.
The development of optical fibers capable of transmitting laser energy has encouraged the experimental use of laser irradiation for the treatment of acquired cardiovascular disorders. One of the key questions is which combination of laser source, energy parameters, and transmitting fiberoptic would be best suited for intravascular use. In most experiments argon, neodymium-YAG, and excimer lasers, coupled to suitable optical fibers, have been used. We now describe the use of a carbon dioxide fiberoptic laser catheter for the creation of an atrial septal defect. Silver halide infrared transmitting fibers were inserted into standard 6 French cardiovascular catheters. This laser catheter system, capable of transmitting several watts of pulsed CO2 laser energy, was initially used to create atrial septal defects in isolated dog hearts to determine the best energy parameters. Atrial septostomy was later performed successfully in four of five anesthetized dogs. The thermal damage extended 50 to 60 micron beyond the "holes" created by the laser irradiation in the interatrial septum. Thus, pulsed CO2 laser irradiation, delivered through optical fibers, can create an atrial septal defect.
能够传输激光能量的光纤的发展，推动了激光照射在获得性心血管疾病治疗中的实验应用。关键问题之一是哪种激光源、能量参数和传输光纤的组合最适合血管内使用。在大多数实验中，已使用与合适光纤耦合的氩激光、钕钇铝石榴石激光和准分子激光。我们现在描述使用二氧化碳光纤激光导管制造房间隔缺损的情况。将卤化银红外传输光纤插入标准的6法式心血管导管中。这种能够传输数瓦脉冲二氧化碳激光能量的激光导管系统，最初用于在离体犬心脏中制造房间隔缺损，以确定最佳能量参数。后来在五只麻醉犬中的四只中成功进行了房间隔造口术。热损伤在房间隔中激光照射产生的“孔”之外延伸了50至60微米。因此，通过光纤传输的脉冲二氧化碳激光照射可以制造房间隔缺损。
