Lee G, Ikeda R M, Stobbe D, Ogata C, Embi A, Chan M C, Reis R L, Mason D T
Cathet Cardiovasc Diagn. 1984;10(1):11-6. doi: 10.1002/ccd.1810100104.
Since laser energy has been shown to produce controlled thermal injury to atherosclerotic plaques from postmortem human hearts, a 3-mm diameter fiberoptic catheter was devised and tested for use in peripheral vessels. The catheter has channels for viewing, laser delivery, and suction/flushing. In five femoral or carotid arteries from three dogs implanted with near-total human atherosclerotic obstructions, the fiberoptic catheter was capable of viewing and targeting the atherosclerotic plaque for laser irradiation. The plaque was vaporized using 5 watts with time exposures lasting from 2 to 5 sec from an argon-ion laser. In three other animals each implanted with a 3- to 4-cm long segment of human cadaver atherosclerotic vessel, the fiberoptic catheter clearly visualized the internal diseased vascular wall. Thus, this investigation provides the initial demonstration and practicality of applying a flexible dual fiberoptic catheter for simultaneous in vivo visualization and laser vaporization of peripheral atherosclerotic disease.
由于激光能量已被证明可对取自人类尸体心脏的动脉粥样硬化斑块产生可控的热损伤，因此设计并测试了一种直径为3毫米的光纤导管，用于外周血管。该导管有用于观察、激光传输和抽吸/冲洗的通道。在三只植入了近乎完全人类动脉粥样硬化阻塞物的狗的五条股动脉或颈动脉中，光纤导管能够观察并瞄准动脉粥样硬化斑块进行激光照射。使用氩离子激光，以5瓦功率、2至5秒的时间照射，使斑块汽化。在另外三只分别植入一段3至4厘米长的人类尸体动脉粥样硬化血管的动物中，光纤导管清晰地显示出内部病变的血管壁。因此，本研究首次证明了应用柔性双光纤导管同时对外周动脉粥样硬化疾病进行体内可视化和激光汽化的可行性。
