Pharmacogenomics Unit, Department of Genetics, Institut Curie, 75005 Paris, France.
Cells. 2021 Apr 29;10(5):1051. doi: 10.3390/cells10051051.
The WW domain-containing oxidoreductase gene () was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.
WW 结构域包含的氧化还原酶基因 () 21 年前被克隆，作为一个假定的肿瘤抑制基因，定位于染色体脆性位点 FRA16D。在人类癌症中经常改变的染色体区域中的 的定位，引发了目前的多项研究，以确定其在这种疾病中的作用。所有这些工作表明，由于 WWOX 能够与大量的合作伙伴相互作用，它通过广泛的分子作用发挥其肿瘤抑制活性，这些作用大多是细胞特异性的。
