Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Department of Neuroradiology, Oxford University Hospital NHS Foundation Trust, Oxford, UK.
Interv Neuroradiol. 2022 Feb;28(1):92-103. doi: 10.1177/15910199211015042. Epub 2021 May 4.
The use of antiplatelets is widespread in clinical practice. However, for neurointerventional procedures, protocols for antiplatelet use are scarce and practice varies between individuals and institutions. This is further complicated by the quantity of antiplatelet agents which differ in route of administration, dosage, onset of action, efficacy and ischemic and hemorrhagic complications. Clarifying the individual characteristics for each antiplatelet agent, and their associated risks, will increasingly become relevant as the practice of mechanical thrombectomy, stenting, coiling and flow diversion procedures grows. The aim of this review is to summarize the existing literature for the use of P2Y12 inhibitors in neurointerventional procedures, examine the quality of the evidence, and highlight areas in need of further research.
抗血小板药物在临床实践中应用广泛。然而，对于神经介入手术，抗血小板药物的使用方案很少，并且个人和机构之间的做法存在差异。由于抗血小板药物的种类繁多，包括给药途径、剂量、作用时间、疗效以及缺血和出血并发症等方面的差异，使得情况更加复杂。随着机械血栓切除术、支架置入术、线圈栓塞术和血流导向装置术等治疗方法的应用日益增多，明确每种抗血小板药物的个体特征及其相关风险将变得越来越重要。本综述的目的是总结神经介入手术中使用 P2Y12 抑制剂的现有文献，评估证据质量，并强调需要进一步研究的领域。
