Dubin N H, Beck J C, Johnson J W, London W T, Ghodgaonkar R B, Perlstein M J
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine.
Am J Obstet Gynecol. 1988 Jul;159(1):233-7. doi: 10.1016/0002-9378(88)90527-3.
Glucocorticoids delay parturition in rhesus monkeys, but the mechanism is unknown. This study was designed to determine the relationship between administration of glucocorticoids and prostaglandin levels in late pregnancy. Pregnant rhesus monkeys received intramuscular betamethasone (2 mg/day) from day 120 to day 133 of pregnancy. 13,14-Dihydro-15-keto-prostaglandin F2 alpha, progesterone, estradiol, estrone, and cortisol in amniotic fluid were measured by radioimmunoassay, and progesterone and estradiol were measured in the maternal serum. Among control animals, between 133 days and 160 days there were significant increases in adrenal size (p less than 0.05) and in amniotic fluid 13,14-Dihydro-15-keto-prostaglandin F2a metabolite, (p less than 0.005), estrone, and progesterone concentrations (p less than 0.05). The increase in adrenal size and the rise in amniotic fluid 13,14-Dihydro-15-keto-prostaglandin F2a metabolite, did not occur in betamethasone-treated monkeys. Maternal serum estradiol levels were suppressed immediately after treatment with betamethasone but recovered to control levels by day 160. Other changes in maternal serum and amniotic fluid sex steroid levels were sought but not observed. These data are consistent with the hypothesis that glucocorticoids delay primate parturition by altering intrauterine prostaglandin F2 alpha metabolism.
糖皮质激素可延迟恒河猴分娩，但具体机制尚不清楚。本研究旨在确定妊娠晚期糖皮质激素给药与前列腺素水平之间的关系。妊娠恒河猴在妊娠第120天至第133天接受肌肉注射倍他米松（2mg/天）。采用放射免疫分析法测定羊水13,14-二氢-15-酮-前列腺素F2α、孕酮、雌二醇、雌酮和皮质醇水平，同时测定母血中孕酮和雌二醇水平。在对照动物中，133天至160天期间，肾上腺大小显著增加（p<0.05），羊水13,14-二氢-15-酮-前列腺素F2α代谢产物、雌酮和孕酮浓度显著升高（p<0.005，p<0.05）。倍他米松治疗的猴子未出现肾上腺大小增加和羊水13,14-二氢-15-酮-前列腺素F2α代谢产物升高的情况。倍他米松治疗后，母血雌二醇水平立即受到抑制，但到第160天恢复至对照水平。未发现母血和羊水性类固醇水平的其他变化。这些数据与糖皮质激素通过改变子宫内前列腺素F2α代谢来延迟灵长类动物分娩的假说一致。
