Mitchell M D, Patrick J E, Robinson J S, Thorburn G D, Challis J R
J Endocrinol. 1976 Oct;71(1):67-76. doi: 10.1677/joe.0.0710067.
Prostaglandin F (PGF) was measured in amniotic fluid, and 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) was measured in maternal peripheral venous plasma and amniotic fluid of rhesus monkeys during late pregnancy. 13,14-Dihydro-15-keto-PGF2 alpha was determined in the maternal peripheral venous plasma of two animals following intra-uterine foetal death. The mean concentration of PGF and PGFM in amniotic fluid increased fourfold during the last 5 days of pregnancy. This increase was associated with an increase in the oestrone concentration in amniotic fluid and in maternal plasma. In normal pregnancy there was no increase in PGFM levels in the maternal peripheral vein, up to 1-2 days pre partum. After intra-uterine death, progesterone concentration in the maternal peripheral vein was unaltered, but oestrone and oestradiol declined. In plasma samples taken within 12 h of delivery, the concentration of PGFM was raised. It is concluded that an increase in prostaglandin production accompanies delivery at normal term, and at delivery past term following intra-uterine foetal death.
在妊娠晚期，对恒河猴的羊水进行前列腺素F（PGF）测定，并对母体外周静脉血浆和羊水进行13,14 - 二氢 - 15 - 酮 - 前列腺素F2α（PGFM）测定。对两只动物在子宫内胎儿死亡后，测定其母体外周静脉血浆中的13,14 - 二氢 - 15 - 酮 - PGF2α。在妊娠最后5天，羊水中PGF和PGFM的平均浓度增加了四倍。这种增加与羊水中和母体血浆中雌酮浓度的增加有关。在正常妊娠中，直至产前1 - 2天，母体外周静脉中PGFM水平均无增加。子宫内胎儿死亡后，母体外周静脉中的孕酮浓度未改变，但雌酮和雌二醇下降。在分娩后12小时内采集的血浆样本中，PGFM浓度升高。得出的结论是，在足月分娩以及子宫内胎儿死亡后的过期分娩时，前列腺素产生均会增加。
