College of Chemistry, Nanchang University, Nanchang, Jiangxi 330088, PR China.
The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330088, PR China.
Mater Sci Eng C Mater Biol Appl. 2021 May;124:112066. doi: 10.1016/j.msec.2021.112066. Epub 2021 Mar 26.
The healing process of open wounds is a competition between cells and bacteria. Therefore, a strategy that can quickly remove bacteria and promote cell proliferation to accelerate wound healing is urgently needed. Inspired by photoelectric synergy tactics, we improved both the optical and electrical response of zinc oxide (ZnO) through the modification of polydopamine (PDA) and reduced graphene oxide (rGO), thus obtaining a ZnO composite named PDA-rGO-ZnO (PrZ). Combined with the photoelectric double stimulation, the sterilization target could be completed from multiple physical levels simultaneously. More importantly, the band gap of ZnO was considerably narrowed by PDA encapsulation. The encapsulated ZnO thus could be effectively excited by pure yellow light (YL) with a moderate long wavelength, which fundamentally improved its safety in exerting photocatalytic antibacterial properties. In addition, we found that electrical stimulation (ES) could not only help to clear bacteria, but also facilitate the formation of new blood vessels. Animal experiments further showed that PrZ efficaciously regulated the immune response around the wound surface, promoted cell proliferation and the formation of collagen fibers, thereby accelerating wound healing.
创面的愈合过程是细胞与细菌之间的竞争。因此，急需一种能够快速清除细菌并促进细胞增殖以加速创面愈合的策略。受光电协同策略的启发，我们通过聚多巴胺（PDA）和还原氧化石墨烯（rGO）的修饰，提高了氧化锌（ZnO）的光学和电学响应，从而获得了一种名为 PDA-rGO-ZnO（PrZ）的 ZnO 复合材料。结合光电双重刺激，可以从多个物理层面同时完成杀菌目标。更重要的是，PDA 封装显著缩小了 ZnO 的带隙。因此，被封装的 ZnO 可以被适度长波长的纯黄光（YL）有效激发，这从根本上提高了其发挥光催化抗菌性能的安全性。此外，我们发现电刺激（ES）不仅有助于清除细菌，还有助于形成新的血管。动物实验进一步表明，PrZ 能有效调节创面周围的免疫反应，促进细胞增殖和胶原纤维的形成，从而加速创面愈合。
