Department of Pediatric Oncology and Hematology, Charité Berlin, Germany.
German Cancer Consortium (DKTK), Berlin, Germany.
Clin Cancer Res. 2021 Jul 1;27(13):3507-3509. doi: 10.1158/1078-0432.CCR-21-0627. Epub 2021 May 4.
Activating mutations of the anaplastic lymphoma kinase () gene were identified in the pediatric tumor neuroblastoma, in 2008. Rapid translation of this finding into targeted neuroblastoma therapy was facilitated by the availability of ALK inhibitors developed for adult malignancies and an efficient preclinical and clinical research program..
2008 年，在儿科肿瘤神经母细胞瘤中发现了间变性淋巴瘤激酶（）基因的激活突变。由于开发了用于成人恶性肿瘤的 ALK 抑制剂和有效的临床前和临床研究计划，这一发现迅速转化为针对神经母细胞瘤的靶向治疗。
