Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Xiang, Dongcheng District, Beijing, 100730, China.
Department of Medical Records and Statistics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Sci Rep. 2021 May 4;11(1):9491. doi: 10.1038/s41598-021-88927-9.
Obesity increases the risk of developing cardiovascular disease and other metabolic diseases. We intended to compare three different anthropometric indicators of obesity, in predicting the incidence of cardiovascular events in Chinese type 2 diabetes. Beijing Community Diabetes Study was a prospective multi-center study conducted in Beijing community health centers. Type 2 diabetes patients from fourteen community health centers were enrolled at baseline. The primary endpoint was cardiovascular events. The upper quartile of neck circumference (NC) was set as greater NC. A total of 3299 diabetes patients were enrolled. In which, 941 (28.52%) had cardiovascular disease at baseline. Logistic analysis showed that central obesity (waist circumference (WC) above 90 cm in men and 85 cm in women) and greater NC were all related to baseline cardiovascular disease (adjusted OR = 1.49, and 1.55). After 10-year follow-up, 340 (10.31%) had cardiovascular events. Compared with patients without cardiovascular events, those having cardiovascular events had higher BMI, larger WC and NC. Cox regression analysis showed that greater WC and NC were all associated with the occurrence of cardiovascular events (adjusted HR = 1.41, and 1.38). A higher NC and WC might increase the risk of cardiovascular events by about 40% in type 2 diabetes patients in Beijing communities.
肥胖增加了患心血管疾病和其他代谢性疾病的风险。我们旨在比较三种不同的肥胖人体测量指标，以预测中国 2 型糖尿病患者发生心血管事件的风险。北京社区糖尿病研究是一项在北京社区卫生中心进行的前瞻性多中心研究。从 14 个社区卫生中心招募了 2 型糖尿病患者作为研究对象。主要终点是心血管事件。颈围（NC）的上四分位数（NC）被设定为较大的 NC。共纳入 3299 例糖尿病患者，其中基线时有 941 例（28.52%）患有心血管疾病。logistic 分析显示，中心性肥胖（男性 WC 大于 90cm，女性大于 85cm）和较大的 NC 均与基线时的心血管疾病相关（调整后的 OR 分别为 1.49 和 1.55）。10 年后随访期间，340 例（10.31%）发生心血管事件。与无心血管事件的患者相比，发生心血管事件的患者 BMI、WC 和 NC 更大。Cox 回归分析显示，较大的 WC 和 NC 均与心血管事件的发生相关（调整后的 HR 分别为 1.41 和 1.38）。较高的 NC 和 WC 可能使北京社区 2 型糖尿病患者发生心血管事件的风险增加约 40%。
