Thunnissen F B, Van Eijk J, Baak J P, Schipper N W, Uyterlinde A M, Breederveld R S, Meijer S
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
Am J Pathol. 1988 Jul;132(1):119-22.
Bronchopulmonary carcinoid tumors are tumors with a low malignant potential. They metastasize in 5-15% of cases. Accurate histologic preoperative prediction of the presence of regional lymph node metastases is not possible at this time. A retrospective quantitative pathologic analysis was performed to investigate the possibility of predicting the presence or absence of regional lymph node metastases in 24 patients with bronchopulmonary carcinoid tumors. The results of univariate analysis showed that large tumor size was associated significantly more frequently with regional lymph node metastases than small tumor size (P less than 0.01). The other quantitative features, ie, a larger mean nuclear area, higher standard deviation of the nuclear area and the presence of an aneuploid DNA index, were frequently associated with regional lymph node metastases, but this tendency was not significant. In multivariate analysis the combination of tumor size and mean nuclear area predicted the presence or absence of regional lymph node metastases correctly in 80 and 94% of the cases, respectively. These results indicate that the combination of tumor size and mean nuclear area may serve as a guideline to predict the presence of regional lymph node metastases.
支气管肺类癌肿瘤是恶性潜能较低的肿瘤。它们在5% - 15%的病例中会发生转移。目前尚无法在术前通过准确的组织学方法预测区域淋巴结转移的存在与否。我们进行了一项回顾性定量病理分析，以研究预测24例支气管肺类癌肿瘤患者区域淋巴结转移存在与否的可能性。单因素分析结果显示，与小肿瘤相比，大肿瘤尺寸与区域淋巴结转移的关联更为频繁（P小于0.01）。其他定量特征，即较大的平均核面积、较高的核面积标准差以及非整倍体DNA指数的存在，虽常与区域淋巴结转移相关，但这种趋势并不显著。在多因素分析中，肿瘤大小和平均核面积的组合分别在80%和94%的病例中正确预测了区域淋巴结转移的存在与否。这些结果表明，肿瘤大小和平均核面积的组合可作为预测区域淋巴结转移存在与否的指导指标。
