Kilduff T S, Sharp F R, Heller H C
Department of Biological Sciences, Stanford University, California 94305.
Am J Physiol. 1988 Jul;255(1 Pt 2):R178-81. doi: 10.1152/ajpregu.1988.255.1.R178.
The paratrigeminal nucleus (Pa5) undergoes a progressive increase in its uptake of 2-[14C]deoxyglucose (2DG) relative to other brain structures during entrance to hibernation in the ground squirrel. This highly significant increase results in the Pa5 becoming the most highly labeled brain region during hibernation, even though it exhibits one of the lowest levels of 2DG uptake in the brain during the nonhibernating state. The progressive activation of the Pa5 observed during entrance is reversed during arousal from hibernation. These observations and the neuroanatomical projections of the Pa5 implicate this nucleus as playing a role in the entrance and maintenance of the hibernating state.
在黄鼠进入冬眠期间，相对于其他脑结构，三叉神经旁核（Pa5）对2-[14C]脱氧葡萄糖（2DG）的摄取呈进行性增加。这种高度显著的增加使得Pa5在冬眠期间成为标记程度最高的脑区，尽管在非冬眠状态下它是脑中2DG摄取水平最低的区域之一。在进入冬眠期间观察到的Pa5的进行性激活在从冬眠中苏醒时会逆转。这些观察结果以及Pa5的神经解剖投射表明，该核在冬眠状态的进入和维持中发挥作用。
