Laboratory of Experimental Neurology , Department of Biomedical Sciences , University of the State of Rio Grande do Norte , Brazil.
Acta Neurobiol Exp (Wars). 2021;81(1):58-68. doi: 10.21307/ane-2021-007.
Forced swimming is a common exercise method used for its low cost and easy management, as seen in studies with the hippocampus. Since it is applied for varied research purposes many protocols are available with diverse aspects of physical intensity, time and periodicity, which produces variable outcomes. In the present study, we performed a systematic review to stress the neurobiological effects of forced swim exercise on the rodent hippocampus. Behavior, antioxidant levels, neurotrophins and inflammatory markers were the main topics examined upon the swimming effects. Better results among these analyses were associated with forced exercise at moderate intensity with an adaptation period and the opposite for continuous exhausting exercises with no adaptation. On further consideration, a standard swimming protocol is necessary to reduce variability of results for each scenario investigated about the impact of the forced swimming on the hippocampus. Forced swimming is a common exercise method used for its low cost and easy management, as seen in studies with the hippocampus. Since it is applied for varied research purposes many protocols are available with diverse aspects of physical intensity, time and periodicity, which produces variable outcomes. In the present study, we performed a systematic review to stress the neurobiological effects of forced swim exercise on the rodent hippocampus. Behavior, antioxidant levels, neurotrophins and inflammatory markers were the main topics examined upon the swimming effects. Better results among these analyses were associated with forced exercise at moderate intensity with an adaptation period and the opposite for continuous exhausting exercises with no adaptation. On further consideration, a standard swimming protocol is necessary to reduce variability of results for each scenario investigated about the impact of the forced swimming on the hippocampus.
强迫游泳是一种常见的运动方式，因其成本低、易于管理而被广泛应用于研究海马体的实验中。由于它可用于各种研究目的，因此有许多不同强度、时间和周期性的方案，这些方案产生的结果也各不相同。在本研究中，我们进行了系统评价，以强调强迫游泳运动对啮齿动物海马体的神经生物学影响。行为、抗氧化水平、神经营养因子和炎症标志物是游泳效应主要的研究主题。在这些分析中，更好的结果与中等强度的强迫运动、适应期以及与无适应期的连续耗竭运动相反。进一步考虑，对于每个研究强迫游泳对海马体影响的场景，都需要一个标准的游泳方案来减少结果的变异性。
