Department of Materials Sciences and Engineering, Nagoya Institute of Technology, Gokiso-cyo, Showa-ku, Nagoya 466-8555, Japan.
Life Sci. 2013 Nov 13;93(21):773-7. doi: 10.1016/j.lfs.2013.09.022. Epub 2013 Oct 3.
One of the events in the brain is an increasing cerebral blood flow during exercise. The tissue oxygen level may be increased because blood flow correlates with tissue oxygen level. However, it is little known whether the tissue oxygen pressure in hippocampal region (Hip-pO2) will be affected by exercise.
The aim of this study is to examine Hip-pO2 levels in the hippocampus and its changes during exercise.
We applied improved Clark-type electrodes to measure Hip-pO2 level in the hippocampus of rats that were subjected to three groups, 2h swimming without weights (low intensity, n=6), 2h swimming with a 5 g weight (moderate intensity, n=6), and 2h swimming with a 10 g weight (high intensity, n=6).
Exercise affected the Hip-pO2 level, the responses varied with the exercise intensity and duration. Interestingly during and after the Low intensity swimming the Hip-pO2 level showed long lasting enhancement (10-20% above resting level). But the moderate and high intensity swimming increased Hip-pO2 level at the start of the swimming (50%, P<0.05 and slightly above resting level, respectively, at 10 min of 2h swimming) and then began to decrease (at 120 min and 10 min of 2h swimming, respectively), and suppressed the Hip-pO2 levels during post exercise resting period (2h) (85-95% of resting level, NS and 60-70% of resting level P<0.05, respectively).
We propose that exercise-induced hippocampal hyper/hypo oxygen condition may participate in beneficial exercise effects on brain function.
大脑中的一个事件是运动时脑血流增加。由于血流与组织氧水平相关，组织氧水平可能会增加。然而，运动是否会影响海马区（Hip-pO2）的组织氧压还知之甚少。
本研究旨在检查运动过程中海马区的 Hip-pO2 水平及其变化。
我们应用改良的 Clark 型电极测量未负重（低强度，n=6）、负重 5g（中强度，n=6）和负重 10g（高强度，n=6）的大鼠海马区的 Hip-pO2 水平。
运动影响 Hip-pO2 水平，反应随运动强度和持续时间而变化。有趣的是，在低强度游泳期间和之后，Hip-pO2 水平表现出持久的增强（比静息水平高 10-20%）。但中强度和高强度游泳在游泳开始时会增加 Hip-pO2 水平（分别增加 50%，P<0.05 和略高于静息水平，在 2 小时游泳的 10 分钟时），然后开始下降（在 120 分钟和 2 小时游泳的 10 分钟时），并抑制运动后恢复期（2 小时）的 Hip-pO2 水平（分别为静息水平的 85-95%，NS 和静息水平的 60-70%，P<0.05）。
我们提出，运动诱导的海马区高/低氧条件可能参与了运动对大脑功能的有益影响。
