从 Roxb. 的种仁中分离得到的四个新的卡莎烷型二萜。
Four new cassane-type diterpenoids from the seed kernels of Roxb.
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
出版信息
Nat Prod Res. 2022 Oct;36(19):5032-5038. doi: 10.1080/14786419.2021.1919107. Epub 2021 May 5.
The first investigation of chemical composition in seed kernels of Roxb. resulted in the separation of four new cassane diterpenes, including three furanoditerpenes (, and ) and one tricyclic type (). It was the first found cassane diterpenoids from this plant. Their gross structures were elucidated by means of comprehensive spectroscopic analysis (UV, IR, NMR, HRESIMS) as well as electronic circular dichroism (ECD) calculation. The compound possess a rare isomerized dihydrofuran ring in structure framework. In bioassay, compounds - exhibited moderate anti-inflammatory activity by inhibiting production of NO in LPS-induced RAW 264.7 cells.
首次对罗比（Roxb.）种仁的化学成分进行调查，分离得到了四种新的贝壳杉二萜，包括三种呋喃型二萜（、和）和一种三环型（）。这是首次从该植物中发现贝壳杉二萜类化合物。通过综合光谱分析（UV、IR、NMR、HRESIMS）以及电子圆二色性（ECD）计算，阐明了它们的总体结构。化合物 具有罕见的结构骨架中异构化的二氢呋喃环。在生物测定中，化合物 - 通过抑制 LPS 诱导的 RAW 264.7 细胞中 NO 的产生表现出中等的抗炎活性。
Zotero 插件