Cassane diterpenoids from and their anti-inflammatory and -glycosidase inhibitory activities.

Three undescribed cassane-type diterpenoids (CAs), caesalpulcherrins K-M (-), together with three known ones (-) were isolated from the aerial parts of (L.) Sw (Fabaceae). Their structures were elucidated via analysis of NMR (1 D and 2 D) and HRESIMS data. The character for caesalpulcherrin K possessing the olefin bond at C-11 and C-12 in its cassane skeleton was observed, which belonged to a small group among more than 450 CAs. That is, only fifteen derivatives have been reported up to now, to our knowledge. Biological evaluation revealed that compounds - exhibited moderate anti-inflammatory activity, with an IC value from 6.04 ± 0.34 to 8.92 ± 0.65 μM. Furthermore, compounds and exhibited significant -glucosidase inhibitory activity at 10 μM.