双相障碍中执行功能和工作记忆、肿瘤坏死因子-α（TNF-α）和可溶性 TNF 受体（sTNFR1 和 sTNFR2）之间的认知免疫相互作用。
Cognition-immune interactions between executive function and working memory, tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and sTNFR2) in bipolar disorder.
机构信息
Federal University for Latin American Integration, Foz do Iguacu, Brazil.
Londrina State University, Health Sciences Graduate Program, Londrina, Brazil.
出版信息
World J Biol Psychiatry. 2022 Jan;23(1):67-77. doi: 10.1080/15622975.2021.1925152. Epub 2021 Jun 18.
OBJECTIVES
This study examined cognition-immune interactions, specifically executive function, working memory, peripheral levels of tumour necrosis factor-alpha (TNF-α), and soluble tumour necrosis factor receptors-1 and -2 (sTNFR1 and 2) levels in bipolar disorder (BD) patients in comparison with controls.
METHODS
Thirty-one BD participants and twenty-seven controls participated in the study. The neurocognitive assessment was performed through three of CogState Research Battery tasks for executive function and working memory. Plasma levels of TNF-α, sTNFR1, and sTNFR2 were measured after overnight fasting. Sociodemographic data and symptom severity of depression and mania were assessed.
RESULTS
BD presented a significantly worse performance in the working memory task ( = .005) and higher levels of TNF-α ( = .043) in comparison to controls. A trend level of significance was found for sTNFR1 between groups ( = .082). Among BD participants, there were significant correlations between sTNFR2 and neurocognitive tasks (Groton Maze Learning Task: ρ = .54, = .002; Set-Shifting Task: ρ = .37, = .042; and the Two-Back Task: ρ = -.49, = .005), and between sTNFR1 and mania, depression and anxiety symptoms (respectively ρ = .37, = .038; ρ = -.38, = .037; and ρ = .42, = .002).
CONCLUSION
TNF-α and its receptors might be an important variable in cognitive impairment in BD. Future studies might focus on the development of anti-inflammatory therapeutic targets for cognitive dysfunction in BD.
目的
本研究旨在探讨认知-免疫相互作用，特别是执行功能、工作记忆、肿瘤坏死因子-α（TNF-α）的外周水平以及可溶性肿瘤坏死因子受体-1 和 -2（sTNFR1 和 sTNFR2）在双相障碍（BD）患者中的水平，以与对照组进行比较。
方法
31 名 BD 参与者和 27 名对照者参与了这项研究。通过 CogState Research Battery 的三项执行功能和工作记忆任务进行神经认知评估。空腹过夜后测量血浆 TNF-α、sTNFR1 和 sTNFR2 水平。评估社会人口统计学数据以及抑郁和躁狂的症状严重程度。
结果
BD 在工作记忆任务中的表现明显较差（ = .005），并且 TNF-α 水平较高（ = .043），与对照组相比。组间 sTNFR1 存在趋势水平的显著性差异（ = .082）。在 BD 参与者中，sTNFR2 与神经认知任务之间存在显著相关性（格罗顿迷宫学习任务：ρ = .54， = .002；转换任务：ρ = .37， = .042；以及二背任务：ρ = -.49， = .005），而 sTNFR1 与躁狂、抑郁和焦虑症状之间存在相关性（分别 ρ = .37， = .038；ρ = -.38， = .037；和 ρ = .42， = .002）。
结论
TNF-α 及其受体可能是 BD 认知障碍的一个重要变量。未来的研究可能集中在开发针对 BD 认知功能障碍的抗炎治疗靶点上。
Zotero 插件