Department of Surgery, PGIMER, Chandigarh, India.
Pol Przegl Chir. 2021 Feb 6;93(3):1-5. doi: 10.5604/01.3001.0014.7225.
Postoperative pancreatic fistula is associated with high morbidity and mortality. Studies have reported internal stenting of the pancreaticojejunostomy anastomosis to reduce postoperative pancreatic fistula, but it is still controversial.
Fifty patients undergoing elective pancreaticoduodenectomy, were included. Patients were divided into 2 groups in randomized fashion; Group A (n-25) without internal stenting across the pancreaticojejunostomy anastomosis and Group B (n-25) with internal stenting of the pancreaticojejunostomy anastomosis. Primary endpoint was the occurrence of postoperative pancreatic fistula.
Both the groups were comparable in demographics, co morbidities, pathologies, pancreatic texture and pancreatic duct diameter. Out of 50 patients studied, total 23(46.0%) patients developed postoperative pancreatic fistula. Ten (40%) in group A and 13 (52%) in group B (p 0.156). Sixteen patients (32%) developed Grade A and 7 (14%) patients had Grade B postoperative pancreatic fistula. In group A, 6 patients developed grade A and 4 patients developed grade B postoperative pancreatic fistula. In group B, 10 patients developed grade A and 3 patients developed grade B postoperative pancreatic fistula. There was no Grade C fistula. All patients had satisfactory recovery on conservative management. Eight patients (16%) developed delayed gastric emptying [5 in group A and 3 in group B; p-0.366]. Six patients developed superficial surgical site infection (2 in group A and 4 in group B; p-0.445). The length of hospital stay was comparable in two groups. There was no mortality.
Internal stenting of pancreaticojejunostomy anastomosis does not decrease the rate of postoperative pancreatic fistula after pancreaticoduodenectomy.
术后胰瘘与高发病率和死亡率相关。有研究报道,通过对胰肠吻合口进行内部支架置入来减少术后胰瘘,但仍存在争议。
共纳入 50 例行择期胰十二指肠切除术的患者。患者以随机方式分为 2 组;A 组(n=25)未对胰肠吻合口进行内部支架置入,B 组(n=25)对胰肠吻合口进行内部支架置入。主要终点是术后胰瘘的发生情况。
两组患者在人口统计学、合并症、病理、胰腺质地和胰管直径方面均具有可比性。在 50 例研究患者中,共有 23 例(46.0%)患者发生术后胰瘘。A 组 10 例(40%),B 组 13 例(52%)(p=0.156)。16 例(32%)患者发生 A 级胰瘘,7 例(14%)患者发生 B 级胰瘘。A 组中,6 例患者发生 A 级胰瘘,4 例患者发生 B 级胰瘘。B 组中,10 例患者发生 A 级胰瘘,3 例患者发生 B 级胰瘘。无 C 级瘘。所有患者经保守治疗均恢复良好。8 例(16%)患者发生延迟性胃排空[A 组 5 例,B 组 3 例;p=0.366]。6 例患者发生浅表性手术部位感染(A 组 2 例,B 组 4 例;p=0.445)。两组患者的住院时间无差异。无死亡病例。
胰十二指肠切除术后,对胰肠吻合口进行内部支架置入并不能降低术后胰瘘的发生率。