N-标记杂环的合成：苯胺和甘氨酸-N的C-N键的裂解

Synthesis of N-labeled heterocycles the cleavage of C-N bonds of anilines and glycine-N.

作者信息

He Jiwen, Zhang Xingguo, He Qiuqin, Guo Hao, Fan Renhua

机构信息

Academy for Engineering and Technology, Fudan University, 220 Handan Road, Shanghai 200433, China.

College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.

出版信息

Chem Commun (Camb). 2021 Jun 1;57(44):5442-5445. doi: 10.1039/d1cc01734a.

DOI:10.1039/d1cc01734a

PMID:33949517

Abstract

A nitrogen replacement process that directly incorporates the 15N atom of glycine-15N into anilines was reported. The process involves a Csp2-N bond cleavage of anilines driven by dearomatization and a Csp3-N bond cleavage of glycine-15N driven by aromatization. A variety of 15N-labeled aromatic heterocycles can be prepared via this process.

摘要

报道了一种直接将甘氨酸 - 15N的15N原子引入苯胺的氮置换过程。该过程涉及由去芳构化驱动的苯胺的Csp2 - N键裂解以及由芳构化驱动的甘氨酸 - 15N的Csp3 - N键裂解。通过该过程可以制备多种15N标记的芳香杂环化合物。