Asrorov Akmal M, Gu Zeyun, Li Feng, Liu Lingyun, Huang Yongzhuo
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Nanoscale. 2021 May 20;13(19):8693-8706. doi: 10.1039/d1nr01127h.
Cancer remains a significant challenge despite the progress in developing different therapeutic approaches. Nanomedicine has been explored as a promising novel cancer therapy. Recently, biomimetic camouflage strategies have been investigated to change the bio-fate of therapeutics and target cancer cells while reducing the unwanted exposure on normal tissues. Endogenous components (e.g., proteins, polysaccharides, and cell membranes) have been used to develop anticancer drug delivery systems. These biomimetic systems can overcome biological barriers and enhance tumor cell-specific uptake. The tumor-targeting mechanisms include ligand-receptor interactions and stimuli-responsive (e.g., pH-sensitive and light-sensitive) delivery. Drug delivery carriers composed of endogenous components represent a promising approach for improving cancer treatment efficacy. In this paper, different biomimetic drug delivery strategies for cancer treatment are reviewed with a focus on the discussion of their advantages and potential applications.
尽管在开发不同治疗方法方面取得了进展，但癌症仍然是一个重大挑战。纳米医学已被探索为一种有前途的新型癌症治疗方法。最近，人们研究了仿生伪装策略，以改变治疗药物的生物命运并靶向癌细胞，同时减少对正常组织的不必要暴露。内源性成分（如蛋白质、多糖和细胞膜）已被用于开发抗癌药物递送系统。这些仿生系统可以克服生物屏障并增强肿瘤细胞特异性摄取。肿瘤靶向机制包括配体-受体相互作用和刺激响应（如pH敏感和光敏感）递送。由内源性成分组成的药物递送载体是提高癌症治疗效果的一种有前途的方法。本文综述了用于癌症治疗的不同仿生药物递送策略，重点讨论了它们的优点和潜在应用。
