Department of Epidemiology and Data Science, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Int J Environ Health Res. 2022 Jul;32(7):1432-1446. doi: 10.1080/09603123.2021.1888894. Epub 2021 May 5.
This paper describes the findings of a historical cohort study of men and women born around the time of the Dutch famine 1944-45. It provided the first direct evidence in humans of the lasting consequences of prenatal undernutrition. The effects of undernutrition depended on its timing during gestation, and the organs and tissues undergoing periods of rapid development at that time. Early gestation appeared to be particularly critical, with the effects of undernutrition being most apparent, even without reductions in size at birth. Undernutrition during gestation affected the structure and function of organs and tissues, altered behaviour and increased risks of chronic degenerative diseases. This demonstrates the fundamental importance of maternal nutrition during gestation as the building blocks for future health.
本文描述了一项针对出生于 1944-1945 年荷兰饥荒时期的男性和女性的历史队列研究结果。它首次为人类提供了产前营养不良长期后果的直接证据。营养不良的影响取决于其在妊娠期的时间，以及当时处于快速发育阶段的器官和组织。早期妊娠似乎特别关键，即使没有出生体重减轻，营养不良的影响也最为明显。妊娠期营养不良会影响器官和组织的结构和功能，改变行为并增加慢性退行性疾病的风险。这表明，妊娠期间的母体营养对于未来健康的重要性。
