Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
BMJ Open. 2021 Mar 4;11(3):e042078. doi: 10.1136/bmjopen-2020-042078.
The Dutch famine birth cohort study was set up to investigate the effects of acute maternal undernutrition of the 1944-1945 Dutch famine during the specific stages of gestation on later health, with a particular focus on chronic cardiovascular and metabolic diseases, ageing and mental health.
The Dutch famine birth cohort consists of 2414 singletons born alive and at term in the Wilhelmina Gasthuis in Amsterdam around the time of the Dutch famine (1943-1947) whose birth records have been kept. The cohort has been traced and studied since 1994, when the first data collection started. The cohort has been interviewed and physically examined in several waves of data collection since that time, allowing repeated measures of a wide range of phenotypic information as well as the collection of biological samples (blood, urine, buccal swabs), functional testing (of heart, lungs, kidney, HPA axis) and imaging of the brain (MRI) and vasculature (ultrasound). Additionally, genetic and epigenetic information was collected. Through linkage with registries, mortality and morbidity information of the entire cohort has been obtained.
Prenatal famine exposure had lasting consequences for health in later life. The effects of famine depended on its timing during the gestation and the organs and tissues developing at that time, with most effects after exposure to famine in early gestation. The effects of famine were widespread and affected the structure and function of many organs and tissues, resulted in altered behaviour and increased risks of chronic degenerative diseases and increased mortality. The effects of famine were independent of size at birth, which suggests that programming may occur without altering size at birth.
As the cohort ages, we will be assessing the effects of prenatal undernutrition on (brain) ageing, cognitive decline and dementia, as well as overall morbidity and mortality.
The Dutch famine birth cohort is not linked to a clinical trial.
荷兰饥荒出生队列研究旨在调查 1944-1945 年荷兰饥荒期间孕妇急性营养不良对后期健康的影响，特别是关注慢性心血管和代谢疾病、衰老和心理健康。
荷兰饥荒出生队列由 2414 名在阿姆斯特丹威廉敏娜医院足月出生的单胎活产儿组成，这些婴儿出生于荷兰饥荒期间（1943-1947 年），其出生记录得以保留。自 1994 年开始首次数据收集以来，该队列一直被追踪和研究。自那时以来，该队列已多次接受访谈和体检，进行了多次数据收集，从而可以重复测量广泛的表型信息，并收集生物样本（血液、尿液、口腔拭子）、功能测试（心脏、肺、肾脏、HPA 轴）和大脑（MRI）和血管（超声）成像。此外，还收集了遗传和表观遗传信息。通过与登记处的联系，获得了整个队列的死亡率和发病率信息。
产前饥荒暴露对以后的健康有持久的影响。饥荒的影响取决于其在妊娠期间的时间以及当时发育的器官和组织，大多数影响发生在妊娠早期暴露于饥荒之后。饥荒的影响广泛，影响了许多器官和组织的结构和功能，导致行为改变、慢性退行性疾病风险增加和死亡率增加。饥荒的影响独立于出生时的大小，这表明编程可能在不改变出生时大小的情况下发生。
随着队列年龄的增长，我们将评估产前营养不良对（大脑）衰老、认知能力下降和痴呆以及整体发病率和死亡率的影响。
荷兰饥荒出生队列与临床试验无关。
