Cullen J M, Wilson M, Hagler W M, Ort J F, Cole R J
Department of Microbiology, Parasitology, and Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Am J Vet Res. 1988 May;49(5):728-31.
Cyclopiazonic acid dissolved in corn oil was administered by gavage to broiler chicks (n = 80) daily, from the day of hatching for 23 days. Chicks were assigned to 3 groups (1, 2, or 4 mg of cyclopiazonic acid/kg of body weight); a control group was given corn oil. Each group was composed of 10 male and 10 female chicks. Surviving chicks were euthanatized and necropsied on day 24. Histologic examination revealed that the most common lesions consisted of necrosis and hemorrhage or hyperplasia of the mucosa of the proventriculus and hepatocellular vacuolation. Skeletal muscle degeneration, characterized by myofiber swelling or fragmentation accompanied by an infiltrate of macrophages and heterophils, was detected in the group given 4 mg/kg. This degeneration was associated with an increase of plasma creatine kinase activity. Focal hepatocellular and splenic necrosis also developed in the groups given 4 mg/kg.
将溶于玉米油的环匹阿尼酸从孵化日起每天经口灌胃给予80只肉鸡雏鸡，持续23天。雏鸡被分为3组（环匹阿尼酸剂量分别为1、2或4毫克/千克体重）；对照组给予玉米油。每组由10只雄性雏鸡和10只雌性雏鸡组成。在第24天对存活的雏鸡实施安乐死并进行剖检。组织学检查显示，最常见的病变包括腺胃黏膜坏死、出血或增生以及肝细胞空泡化。在给予4毫克/千克剂量的组中检测到骨骼肌变性，其特征为肌纤维肿胀或断裂，并伴有巨噬细胞和异嗜性粒细胞浸润。这种变性与血浆肌酸激酶活性增加有关。给予4毫克/千克剂量的组中还出现了局灶性肝细胞和脾脏坏死。
