Balachandran C, Parthasarathy K R
Department of Pathology, Veterinary College and Research Institute, Namakkal, India.
Mycopathologia. 1995;132(3):161-6. doi: 10.1007/BF01103982.
Three hundred and forty-eight Vencob broiler chickens were fed diets containing Penicillium griseofulvum rice culture material with 0, 12.5, 25 and 50 ppm of the mycotoxin cyclopiazonic acid (CPA) for 28 days. Serum samples were collected from 9 birds in each group at weekly intervals to study the effect of sublethal doses of CPA on certain serum biochemical parameters. Significant reductions in weight gains (p < 0.01) and feed consumptions (p < 0.05) were observed at 25 and 50 ppm. Exocrine pancreas showed degenerative and necrotic changes in CPA fed chickens. The CPA had significant (p < 0.05) influence on serum total protein, albumin, cholesterol, amylase and lipase levels. CPA did not affect serum glucose levels. There was a decline in levels of total serum protein and albumin in CPA fed groups. But serum cholesterol, amylase and lipase showed dose-dependent increases.
348只温可肉鸡被喂食含有不同剂量桔青霉大米培养物的日粮，其中环匹阿尼酸（CPA）的含量分别为0、12.5、25和50 ppm，持续28天。每周从每组中选取9只鸡采集血清样本，以研究亚致死剂量的CPA对某些血清生化参数的影响。在25 ppm和50 ppm剂量组中，观察到体重增加（p < 0.01）和采食量（p < 0.05）显著降低。喂食CPA的鸡的外分泌胰腺出现退行性和坏死性变化。CPA对血清总蛋白、白蛋白、胆固醇、淀粉酶和脂肪酶水平有显著影响（p < 0.05）。CPA不影响血清葡萄糖水平。喂食CPA的组中血清总蛋白和白蛋白水平下降。但血清胆固醇、淀粉酶和脂肪酶呈剂量依赖性增加。
