Ponsky J, McCollister D M, Aszodi A, Grzonka R, Ponsky L
Department of Surgery, Mt. Sinai Medical Center, Cleveland, Ohio.
Am Surg. 1988 Aug;54(8):517-8.
The small bowel may be subjected to transient, yet reversible ischemia in situations such as volvulus, thromboembolism, and low flow states. The surgeon is frequently faced with the necessity of intestinal resection in treating such cases. The remaining bowel, while judged viable may have been exposed to significant ischemic injury. The surgeon must decide whether such bowel will heal satisfactorily if used in an anastomosis. This study was undertaken to determine the effect of transient ischemia on intestinal anastomotic healing in the rat. Male albino rats were subjected to superior mesenteric artery occlusion for periods of 30 minutes or 45 minutes. The circulation was then re-established. The small bowel was the transected and anastomosed. Animals in each group were sacrificed at 7 and 10 days and bursting pressures performed to test the healing of the anastomosis. Results were compared with a control group having an anastomosis without precedent ischemia. There were no significant differences among the groups. The data clearly indicate that if the bowel remains viable following an ischemic insult its healing is unimpaired.
在诸如肠扭转、血栓栓塞和低血流状态等情况下，小肠可能会遭受短暂但可逆的缺血。在治疗此类病例时，外科医生常常面临进行肠切除的必要性。剩余的肠管虽然被判定为存活，但可能已经遭受了严重的缺血性损伤。外科医生必须决定，如果将这样的肠管用于吻合术，它是否能够顺利愈合。本研究旨在确定短暂性缺血对大鼠肠吻合口愈合的影响。雄性白化大鼠接受肠系膜上动脉阻断30分钟或45分钟。然后恢复血液循环。将小肠横断并进行吻合。每组动物在第7天和第10天处死，并测量吻合口的破裂压力以测试吻合口的愈合情况。结果与未经历过缺血的吻合术对照组进行比较。各组之间没有显著差异。数据清楚地表明，如果肠管在缺血损伤后仍保持存活，其愈合不受影响。
