Mayo Clinic Arizona Department of Orthopedics, Phoenix, AZ, 85054, USA.
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA.
Spine Deform. 2021 Nov;9(6):1641-1647. doi: 10.1007/s43390-021-00359-7. Epub 2021 May 5.
The purpose of this study was to evaluate the peri-operative outcomes of patients with Prader-Willi Syndrome (PWS) undergoing spinal deformity correction and compare the outcomes to patients with adolescent idiopathic scoliosis (AIS).
A retrospective review of the Kid's Inpatient Database was performed from 2000 to 2012 to identify all pediatric patients with scoliosis undergoing spinal fusion. Cohorts were created on the basis of PWS diagnosis and adolescent idiopathic scoliosis. Statistical analysis was performed for differences in post-operative outcomes between these two patient cohorts.
Between 2000 and 2012, the number of spinal fusions performed increased by 24.6 and 32.2% in the PWS and adolescent idiopathic scoliosis populations, respectively. There was no difference between the incidence of major complications in PWS patients when compared to AIS (1.7% vs. 1.0% in idiopathic scoliosis; p = 0.362). Although there was no significant difference in the rate of overall minor complications, PWS patients were demonstrated to be more likely to experience post-operative pneumonia (p < 0.0001) and implant complications (p < 0.001).
Patients with scoliosis associated with PWS do not have any increased risk of major complications following spinal deformity correction when compared to patients with adolescent idiopathic scoliosis. Two important minor complications to keep in mind when surgically treating scoliosis in PWS patients include pulmonary and implant-related complications.
Retrospective comparative study, Level III.
本研究旨在评估普拉德-威利综合征（PWS）患者脊柱畸形矫正的围手术期结果，并与青少年特发性脊柱侧凸（AIS）患者的结果进行比较。
对 2000 年至 2012 年儿童住院数据库进行回顾性分析，以确定所有接受脊柱融合术的脊柱侧凸患儿。根据 PWS 诊断和青少年特发性脊柱侧凸创建队列。对这两个患者队列之间术后结果的差异进行了统计分析。
在 2000 年至 2012 年间，PWS 和青少年特发性脊柱侧凸人群中分别有 24.6%和 32.2%的患者接受了脊柱融合术。与 AIS 相比，PWS 患者的重大并发症发生率没有差异（1.7%比特发性脊柱侧凸 1.0%；p=0.362）。虽然总体小并发症发生率没有显著差异，但 PWS 患者术后肺炎（p<0.0001）和植入物并发症（p<0.001）的发生率更高。
与青少年特发性脊柱侧凸患者相比，脊柱畸形矫正后 PWS 相关性脊柱侧凸患者的重大并发症风险没有增加。在对 PWS 患者进行脊柱侧凸手术治疗时，需要特别注意两种重要的小并发症，包括肺部和植入物相关并发症。
回顾性比较研究，III 级。
