Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Medicine (Baltimore). 2021 May 7;100(18):e25767. doi: 10.1097/MD.0000000000025767.
To investigate the effect of cervical cerclage or conservative treatment on maternal and neonatal outcomes in singleton gestations with a sonographic short cervix, and further compare the relative treatment value.A retrospective study was conducted among women with singleton gestations who had a short cervical length (<25 mm) determined by ultrasound during the period of 14 to 24 weeks' gestation in our institution. We collected clinical data and grouped the patients according to a previous spontaneous preterm birth (PTB) at <34 weeks of gestation or second trimester loss (STL) and sub-grouped according to treatment option, further comparing the maternal and neonatal outcomes between different groups.In the PTB or STL history cohort, the cerclage group had a later gestational age at delivery (35.3 ± 3.9 weeks vs 31.6 ± 6.7 weeks) and a lower rate of perinatal deaths (2% vs 29.3%) compared with the conservative treatment group. In the non-PTB-STL history cohort, the maternal and neonatal outcomes were not significantly different between the cerclage group and conservative treatment group. More importantly, for patients with a sonographic short cervix who received cervical cerclage, there was no significant difference in the maternal and neonatal outcomes between the non-PTB-STL group and PTB or STL group.For singleton pregnant with a history of spontaneous PTB or STL and a short cervical length (<25 mm), cervical cerclage can significantly improve maternal and neonatal outcomes; however, conservative treatment (less invasive and expensive than cervical cerclage) was more suitable for those pregnant women without a previous PTB and STL history.
探讨经阴道超声测量宫颈短于 25mm 的单胎妊娠行宫颈环扎术或保守治疗对母婴结局的影响,并进一步比较其相对治疗价值。
本研究为回顾性队列研究,纳入在我院行经阴道超声检查发现宫颈长度<25mm 的单胎妊娠孕妇,收集其临床资料,根据是否有自发性早产史(<34 周)或中孕期流产史分组,根据治疗方案进一步分组,比较不同组间母婴结局。
在自发性早产史或中孕期流产史组中,与保守治疗组相比,行宫颈环扎术组的分娩孕周更晚(35.3±3.9 周 vs. 31.6±6.7 周),围产儿病死率更低(2% vs. 29.3%)。在无自发性早产史或中孕期流产史组中,宫颈环扎术组与保守治疗组的母婴结局差异无统计学意义。更重要的是,对于行宫颈环扎术的宫颈短孕妇,无论是否有自发性早产史或中孕期流产史,其母婴结局差异均无统计学意义。
对于有自发性早产史或中孕期流产史且宫颈短(<25mm)的单胎妊娠孕妇,行宫颈环扎术可明显改善母婴结局;但对于无自发性早产史和中孕期流产史的孕妇,行保守治疗(相对于宫颈环扎术创伤更小、花费更少)可能更适合。