血清钾水平与 HBV 相关失代偿性肝硬化的预后。
Serum potassium levels and prognosis in HBV-associated decompensated cirrhosis.
机构信息
Department of Critical Care Medicine, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China.
Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China.
出版信息
J Clin Lab Anal. 2021 Jun;35(6):e23775. doi: 10.1002/jcla.23775. Epub 2021 May 5.
BACKGROUND
Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV-related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV-DeCi patients.
METHODS
Retrospective study included 155 subjects. Multivariate analysis was used to determine the independent prognostic factor. Predictive ability of mortality for variables was determined using the receiver operating characteristics curves.
RESULTS
The 30-day in-hospital mortality was 12.9%. Serum potassium levels differed markedly between survivors and non-survivors. On multivariate analysis, Model for End-Stage Liver Disease (MELD) score and serum potassium level were identified as independent predictors of outcomes in HBV-DeCi patients. The combination of serum potassium and MELD score could improve prognostic accuracy in these patients.
CONCLUSIONS
Our findings suggest that serum potassium is an effective predictor for poor outcomes in HBV-DeCi patients.
背景
血清钾紊乱在晚期肝硬化患者中很常见，对临床预后有不良影响，但在乙型肝炎相关失代偿性肝硬化（DeCi）中的作用仍有待阐明。我们旨在评估血清钾对乙型肝炎 DeCi 患者结局的影响。
方法
回顾性研究纳入了 155 例患者。采用多变量分析确定独立预后因素。采用受试者工作特征曲线确定变量对死亡率的预测能力。
结果
30 天院内死亡率为 12.9%。幸存者和非幸存者的血清钾水平差异显著。多变量分析显示，终末期肝病模型评分和血清钾水平是乙型肝炎 DeCi 患者预后的独立预测因素。血清钾和 MELD 评分的组合可提高这些患者的预后准确性。
结论
我们的研究结果表明，血清钾是乙型肝炎 DeCi 患者不良预后的有效预测指标。
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