Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou 312400, China.
Biomed Res Int. 2022 Feb 14;2022:5754790. doi: 10.1155/2022/5754790. eCollection 2022.
The prognostic role of hemoglobin-to-red blood cell distribution width ratio (HRR) in HBV-related decompensated cirrhosis (HBV-DeCi) has not been established. The present study is aimed at determining the potential of HRR as a predictive factor for the prognosis of HBV-DeCi patients.
The study included 177 HBV-DeCi patients. The clinical outcome was death at 30 days. Multivariate regression analysis and receiver operating characteristic curve analysis were applied to assess the predictive value of HRR for poor outcomes.
A total of 26 patients (14.7%) had died by 30 days. Patients with unfavorable outcomes had lower HRR than patients with favorable outcomes. Multivariate analysis revealed that HRR and Model for End-Stage Liver Disease (MELD) score were independently associated with poor outcomes. Combination of HRR and MELD score may improve prognostic accuracy in HBV-DeCi.
The present findings indicate that low HRR may be a promising predictor for mortality in HBV-DeCi patients.
血红蛋白与红细胞分布宽度比值（HRR）在乙型肝炎相关失代偿性肝硬化（HBV-DeCi）中的预后作用尚未确定。本研究旨在确定 HRR 作为预测 HBV-DeCi 患者预后的潜在因素。
本研究纳入了 177 例 HBV-DeCi 患者。临床结局为 30 天内死亡。采用多变量回归分析和受试者工作特征曲线分析评估 HRR 对不良结局的预测价值。
共有 26 例患者（14.7%）在 30 天内死亡。预后不良的患者 HRR 低于预后良好的患者。多变量分析显示，HRR 和终末期肝病模型（MELD）评分与不良结局独立相关。HRR 和 MELD 评分的联合可提高 HBV-DeCi 的预后准确性。
本研究结果表明，低 HRR 可能是预测 HBV-DeCi 患者死亡的有前途的指标。
