Aachen-Maastricht Institute for Biobased Materials (AMIBM), Faculty of Science and Engineering, Maastricht University, Geleen, 6167 RD, The Netherlands.
Department of Biohybrid and Medical Textiles (BioTex), AME-Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, 52074, Germany.
Macromol Biosci. 2021 Jul;21(7):e2100021. doi: 10.1002/mabi.202100021. Epub 2021 May 5.
Drug-eluting medical textiles have recently gained great attention to be used in different applications due to their cost effectiveness and unique physical and chemical properties. Using various fiber production and textile fabrication technologies, fibrous constructs with the required properties for the target drug delivery systems can be designed and fabricated. This review summarizes the current advances in the fabrication of drug-eluting medical textiles. Different fiber production methods such as melt-, wet-, and electro-spinning, and textile fabrication techniques such as knitting and weaving are explained. Moreover, various loading processes of bioactive agents to obtain drug-loaded fibrous structures with required physicochemical and morphological properties, drug delivery mechanisms, and drug release kinetics are discussed. Finally, the current applications of drug-eluting fibrous systems in wound care, tissue engineering, and transdermal drug delivery are highlighted.
载药医用纺织品由于其成本效益和独特的物理化学性质，最近在各个应用领域受到了极大的关注。通过使用各种纤维生产和纺织制造技术，可以设计和制造具有所需性能的纤维结构，以满足目标药物输送系统的要求。本综述总结了载药医用纺织品制造的最新进展。解释了不同的纤维生产方法，如熔融纺丝、湿法纺丝和静电纺丝，以及纺织制造技术，如针织和编织。此外，还讨论了将生物活性剂负载到纤维结构中以获得具有所需物理化学和形态特性、药物输送机制和药物释放动力学的载药纤维结构的各种加载工艺。最后，强调了载药纤维系统在伤口护理、组织工程和透皮药物输送方面的当前应用。
