Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK; Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW10TU London, UK.
Cell Metab. 2021 May 4;33(5):853-855. doi: 10.1016/j.cmet.2021.04.013.
Mitochondria cover several functions within the cell, including an influence on the transcription of nuclear genes. Recent work by Tigano et al. (2021) in Nature has identified a pathway of mitochondrial retrograde communication in which the nucleus senses aberrations in the mtDNA to drive the innate immune response.
线粒体在细胞内承担着多种功能，包括对核基因转录的影响。最近，Tigano 等人（2021）在《自然》杂志上的研究发现了一条线粒体逆行通讯途径，其中细胞核感知 mtDNA 的异常，从而驱动先天免疫反应。
