Gueddana N, Saffen S, Ben Aissa R, Khemiri F, Chaker A, Arouji A, Hammami A, Lamine-Jomni S
Centre PMI Zouhour, Tunis.
Arch Fr Pediatr. 1988 Mar;45(3):207-11.
This study was aimed at identifying the relative importance of the various agents responsible for gastroenteritis and to contribute to the etiopathogeny of this condition. Four hundred and two samples of stools of patients and 209 of control subjects, all under 3 years of age, were submitted to bacteriological, parasitologic and virologic examinations. An enteral etiology of gastroenteritis was found in 50% of the children. It consisted of enteropathogenic bacteria in 11%, rotaviruses in 29% and both associated in 19% of cases. There was a significant difference between patients and controls for bacterial (p less than 0.0001) and viral (p less than 0.00001) infestation. The most frequently isolated bacteria consisted overall of Escherichia coli. Eighty-seven isolated strains of E. Coli were tested for their enterotoxinogenic capacities. Four strains were bearing the attachment factor (EAF) and 14 were toxinogenic. Shiga-like toxin (or vero toxin) was detected in 4 strains. Campylobacter was isolated as frequently in patients as in controls and was often associated with other bacteria or rotaviruses. The presence of parasites and candidas was not significantly different in patients and in controls. Giardia intestinalis was the most frequently isolated parasite.
本研究旨在确定引起肠胃炎的各种病原体的相对重要性，并为该病症的病因学研究提供帮助。对402份3岁以下患者的粪便样本和209份对照受试者的粪便样本进行了细菌学、寄生虫学和病毒学检查。50%的儿童肠胃炎由肠道病因引起。其中11%由致病性细菌引起，29%由轮状病毒引起，19%由两者共同引起。患者与对照在细菌感染（p<0.0001）和病毒感染（p<0.00001）方面存在显著差异。最常分离出的细菌总体上是大肠杆菌。对87株分离出的大肠杆菌进行了产肠毒素能力检测。4株携带黏附因子（EAF），14株产毒素。4株检测出志贺样毒素（或维罗毒素）。弯曲杆菌在患者和对照中的分离频率相同，且常与其他细菌或轮状病毒相关。患者和对照中寄生虫和念珠菌的存在无显著差异。肠贾第虫是最常分离出的寄生虫。
