Quinonez G, Ragbeer M S, Simon G T
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
Arch Pathol Lab Med. 1988 Aug;112(8):838-41.
This report is, to our knowledge, the first of a gastric carcinoid tumor that, by electron microscopy, revealed pleomorphic neurosecretory granules similar to those found in carcinoid tumors arising from the midgut. On the basis of silver staining, this lesion would be classified as an argentaffin and argyrophil carcinoid tumor, of the type usually associated with midgut derivation. Immunostaining showed the presence of serotonin granules, and there was clinical evidence of intraoperative hyperserotoninemia. The lesion is believed to have arisen from foci of complete intestinal metaplasia, many of which were present in proximity to the site of the lesion and elsewhere in the stomach.
据我们所知，本报告是首例通过电子显微镜检查发现胃类癌肿瘤具有多形性神经分泌颗粒的病例，这些颗粒与在中肠发生的类癌肿瘤中发现的颗粒相似。基于银染色，该病变将被归类为嗜银和亲银类癌肿瘤，通常与中肠起源相关。免疫染色显示存在血清素颗粒，并且有术中高血清素血症的临床证据。据信该病变起源于完全肠化生灶，其中许多存在于病变部位附近以及胃的其他部位。
