Nakagawa Y, Tayama K
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Arch Toxicol. 1988 Apr;61(5):359-65. doi: 10.1007/BF00334616.
A single large dose of butylated hydroxytoluene (BHT, 1000 mg/kg) in male Fischer 344 rats produced some renal damage, reduced accumulation of p-aminohippuric acid in renal slices, proteinuria and enzymuria, in addition to hepatic damage. Further, prior administration of phenobarbital (80 mg/kg, i.p., daily for 4 days) in the high-dose BHT-treated male rats produced renal damage accompanied by slight tubular necrosis. The renal damage was confirmed by biochemical and histological changes. These changes were dose dependent, with a maximum at 24 h after BHT administration, but had returned to the normal range by 48 h. Female rats, on the other hand, were less susceptible to BHT-induced renal and hepatic damage than male rats. The results indicate sex differences in BHT-induced renal or hepatic damage.
给雄性Fischer 344大鼠一次性大剂量给予丁基羟基甲苯（BHT，1000毫克/千克），除了造成肝损伤外，还导致了一些肾损伤，肾切片中对氨基马尿酸的积累减少、蛋白尿和酶尿。此外，在高剂量BHT处理的雄性大鼠中预先给予苯巴比妥（80毫克/千克，腹腔注射，每日一次，共4天）会导致肾损伤，并伴有轻微的肾小管坏死。通过生化和组织学变化证实了肾损伤。这些变化呈剂量依赖性，在BHT给药后24小时达到最大值，但在48小时时已恢复到正常范围。另一方面，雌性大鼠比雄性大鼠对BHT诱导的肾和肝损伤更不敏感。结果表明，BHT诱导的肾或肝损伤存在性别差异。
