Krapf Jill M, Casey Rachel K, Goldstein Andrew T
Gynecology, Center for Vulvovaginal Disorders, Washington, DC, USA
Obstetrics and Gynecology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
BMJ Case Rep. 2021 May 5;14(5):e242653. doi: 10.1136/bcr-2021-242653.
Acute genital ulcers (AGU), known as Lipschütz ulcers, are painful vulvar ulcers typically affecting non-sexually active girls and women. AGU have been associated with viral infections, namely, Epstein-Barr virus (EBV). Here, we describe a case of AGU in the setting of SARS-CoV-2 in a non-sexually active adolescent girl hospitalised for pain control and urinary retention, who failed a course of oral corticosteroids and then improved with colchicine. Testing for herpes simplex virus, EBV and Behcet's syndrome were all negative. Testing for SARS-CoV-2 was positive. COVID-19 increases cytokines such as tumour necrosis factor alpha, which has been shown to affect endothelial cell adhesion and neutrophil chemotaxis, leading to aphthosis.
急性生殖器溃疡（AGU），又称利普许茨溃疡，是一种疼痛性外阴溃疡，通常影响无性活跃的女孩和女性。AGU与病毒感染有关，即爱泼斯坦-巴尔病毒（EBV）。在此，我们描述了一名无性活跃的青少年女孩，因疼痛控制和尿潴留住院，在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的情况下发生AGU的病例。该患者口服皮质类固醇治疗无效，随后使用秋水仙碱病情改善。单纯疱疹病毒、EBV和白塞病检测均为阴性。SARS-CoV-2检测呈阳性。新型冠状病毒肺炎会增加细胞因子，如肿瘤坏死因子α，已证明该因子会影响内皮细胞黏附和中性粒细胞趋化，导致口疮形成。
