与新型冠状病毒肺炎相关的非性传播性反应性急性生殖器溃疡
Reactive non-sexually related acute genital ulcers associated with COVID-19.
作者信息
Krapf Jill M, Casey Rachel K, Goldstein Andrew T
机构信息
Gynecology, Center for Vulvovaginal Disorders, Washington, DC, USA
Obstetrics and Gynecology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
出版信息
BMJ Case Rep. 2021 May 5;14(5):e242653. doi: 10.1136/bcr-2021-242653.
Acute genital ulcers (AGU), known as Lipschütz ulcers, are painful vulvar ulcers typically affecting non-sexually active girls and women. AGU have been associated with viral infections, namely, Epstein-Barr virus (EBV). Here, we describe a case of AGU in the setting of SARS-CoV-2 in a non-sexually active adolescent girl hospitalised for pain control and urinary retention, who failed a course of oral corticosteroids and then improved with colchicine. Testing for herpes simplex virus, EBV and Behcet's syndrome were all negative. Testing for SARS-CoV-2 was positive. COVID-19 increases cytokines such as tumour necrosis factor alpha, which has been shown to affect endothelial cell adhesion and neutrophil chemotaxis, leading to aphthosis.
急性生殖器溃疡（AGU），又称利普许茨溃疡，是一种疼痛性外阴溃疡，通常影响无性活跃的女孩和女性。AGU与病毒感染有关，即爱泼斯坦-巴尔病毒（EBV）。在此，我们描述了一名无性活跃的青少年女孩，因疼痛控制和尿潴留住院，在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的情况下发生AGU的病例。该患者口服皮质类固醇治疗无效，随后使用秋水仙碱病情改善。单纯疱疹病毒、EBV和白塞病检测均为阴性。SARS-CoV-2检测呈阳性。新型冠状病毒肺炎会增加细胞因子，如肿瘤坏死因子α，已证明该因子会影响内皮细胞黏附和中性粒细胞趋化，导致口疮形成。
Zotero 插件