Department of Dermatology and Allergology, Ludwig-Maximilan University, Munich, Germany.
Acta Derm Venereol. 2011 Jan;91(1):55-9. doi: 10.2340/00015555-0979.
Epstein-Barr virus (EBV) infection may rarely be associated with genital ulcers (ulcus vulvae acutum), a very painful manifestation. The aetiopathogenesis of the disease is not fully understood. We describe here a case of an adolescent virgin with multiple, deep genital ulcers associated with acute infectious mononucleosis. The diagnosis was supported by the clinical symptoms, atypical lymphocytosis, elevated circulating levels of liver enzymes, positive EBV serology, and the detection of EBV in a swab sample and a biopsy specimen by PCR. The virus could not be detected by immunohistochemistry or in situ hybridization. After a short course of methylprednisolone as a supportive treatment, the ulcers healed within one month. No relapse occurred during the 2-year follow-up. Available data relating to the aetiopathogenesis of this condition are reviewed, and we speculate that it may have been caused by percutaneous autoinoculation through cervicovaginal fluid.
EB 病毒（EBV）感染偶尔可能与生殖器溃疡（急性外阴溃疡）相关，这是一种非常疼痛的表现。该疾病的病因尚未完全阐明。我们在此描述了一例患有多发、深在性生殖器溃疡的青少年处女，同时伴有急性传染性单核细胞增多症。临床症状、非典型淋巴细胞增多、循环中肝酶水平升高、EBV 血清学阳性，以及 PCR 检测拭子样本和活检标本中 EBV 的存在支持了该诊断。免疫组化或原位杂交均未检测到该病毒。经短期甲基强的松龙支持治疗后，溃疡在一个月内愈合。在 2 年的随访中未复发。我们回顾了与该病症病因相关的现有数据，并推测其可能是通过宫颈阴道液经皮自身接种引起的。
