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核苷酸代谢在癌症发生中的新兴作用:进展与展望。

Emerging roles of nucleotide metabolism in cancer development: progress and prospect.

机构信息

Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Fujian, Xiamen 361000, China.

Department of Gastrointestinal Surgery, Zhongshan Hospital, Xiamen University, Fujian, Xiamen 361000, China.

出版信息

Aging (Albany NY). 2021 May 5;13(9):13349-13358. doi: 10.18632/aging.202962.

Abstract

Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies have shown that abnormal nucleotide metabolism not only accelerates the development of tumors but also inhibits the normal immune response in the tumor microenvironment. Although few relevant experiments and reports are available, study of the interaction between nucleotide metabolism and cancer development is rapidly developing. The intervention, alteration or regulation of molecular mechanisms related to abnormal nucleotide metabolism in tumor cells has become a new idea and strategy for the treatment of tumors and prevention of recurrence and metastasis. Determining how nucleotide metabolism regulates the occurrence and progression of tumors still needs long-term and extensive research and exploration.

摘要

异常的癌症代谢发生在肿瘤发展的全过程中。最近的研究表明,异常核苷酸代谢不仅加速肿瘤的发展,还抑制肿瘤微环境中的正常免疫反应。尽管相关实验和报道较少,但核苷酸代谢与癌症发展之间相互作用的研究正在迅速发展。干预、改变或调节肿瘤细胞中与异常核苷酸代谢相关的分子机制已成为治疗肿瘤、预防复发和转移的新想法和策略。确定核苷酸代谢如何调节肿瘤的发生和进展仍需要长期和广泛的研究和探索。

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