Rubens J, Espeland M A, Ryu J, Harpold G, McKinney W M, Kahl F R, Toole J F, Crouse J R
Department of Medicine, Wake Forest University Medical Center, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
Arteriosclerosis. 1988 Jul-Aug;8(4):389-97. doi: 10.1161/01.atv.8.4.389.
Risk factors for coronary disease were assessed and noninvasive methods were used to quantitate the extent of extracranial carotid atherosclerosis in 382 patients free of cerebrovascular symptoms. The ages of the participants ranged from 27 to 80 years. There were 183 men and 199 women, 30 black and 352 white persons. All patients had heart disease symptoms and were hospitalized for coronary angiography. Correlation of risk factors with extent of extracranial carotid atherosclerosis in this series of patients undergoing coronary angiography uncovered individual variability in relationships between risk factors and carotid atherosclerosis that depended on coronary status. Risk factors for carotid atherosclerosis in patients with and without coronary disease differed. Age and hypertension were independently related to carotid atherosclerosis in patients with, as well as those without, coronary disease. However, other risk factors were related to carotid atherosclerosis in only one group or the other. Risk factors correlated strongly with carotid atherosclerosis in patients with coronary disease (r2 = 0.41) but poorly in those with no coronary disease (r2 = 0.21). Certain risk factors (age, pack years of smoking, left ventricular hypertrophy) related differently to the extent of carotid atherosclerosis in patients with, than in those without, coronary disease. Clarification of the role of coronary status in the carotid atherosclerosis response to risk factors may partly explain the results of certain population-based studies that have related race, gender, and other risk factors to carotid atherosclerosis.(ABSTRACT TRUNCATED AT 250 WORDS)
对382例无脑血管症状的患者评估了冠心病危险因素，并采用非侵入性方法定量检测颅外颈动脉粥样硬化程度。参与者年龄在27至80岁之间。其中男性183例，女性199例，黑人30例，白人352例。所有患者均有心脏病症状并因冠状动脉造影住院。在这一系列接受冠状动脉造影的患者中，危险因素与颅外颈动脉粥样硬化程度的相关性揭示了危险因素与颈动脉粥样硬化之间关系的个体差异，这种差异取决于冠状动脉状况。有冠心病和无冠心病患者的颈动脉粥样硬化危险因素不同。年龄和高血压在有冠心病和无冠心病患者中均与颈动脉粥样硬化独立相关。然而，其他危险因素仅与其中一组的颈动脉粥样硬化有关。危险因素与冠心病患者的颈动脉粥样硬化相关性很强（r2 = 0.41），而与无冠心病患者的相关性较差（r2 = 0.21）。某些危险因素（年龄、吸烟包年数、左心室肥厚）在有冠心病和无冠心病患者中与颈动脉粥样硬化程度的关系不同。阐明冠状动脉状况在颈动脉粥样硬化对危险因素反应中的作用，可能部分解释了某些基于人群的研究结果，这些研究将种族、性别和其他危险因素与颈动脉粥样硬化联系起来。（摘要截短于250字）
