Endo Motochika, Yano Shuya, Asano Hiroaki, Takeda Sho, Hamada Yuki, Kondo Yoshitaka, Kuroda Shinji, Shigeyasu Kunitoshi, Kikuchi Satoru, Tanaka Takehiro, Teraishi Fuminori, Nishizaki Masahiko, Kagawa Shunsuke, Fujiwara Toshiyoshi
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Center for graduate medical education, Okayama University Hospital.
Acta Med Okayama. 2021 Apr;75(2):231-238. doi: 10.18926/AMO/61906.
Targeted therapies for malignant melanoma have improved patients' prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
恶性黑色素瘤的靶向治疗改善了患者的预后。原发性胃肠道恶性黑色素瘤非常罕见，尚无标准治疗策略。我们治疗了一名78岁的日本女性，她患有降结肠和胆囊的晚期原发性胃肠道黑色素瘤。我们进行了多学科治疗：手术切除降结肠和胆囊肿瘤、切除胰头后方的转移淋巴结，并进行了约4年的免疫检查点抗体阻断治疗（纳武单抗）。PET/CT显示3年多无复发病灶。多学科治疗（如手术、化疗、放疗、靶向治疗和免疫检查点抗体阻断治疗）可以成功治疗原发性胃肠道恶性黑色素瘤。
